Blood Brain Barrier and Inflammatory Cell Types in the Human CNS
In our last article, we introduced mast cells, their origins and morphology, and summarized how they are activated during IgE-mediated allergic responses. Here, we shift gears and explore how mast cells, together with microglia and the blood brain barrier, contribute...
Cell of the Month: Mast Cells
Mast cells are tissue-resident immune cells derived from the myeloid lineage, and along with basophils, eosinophils and neutrophils, they belong to the granulocyte family of white blood cells. First discovered and named almost 200 years ago by German pathologist...
Culturing and Characterising Organoids – What Do We Need to Know?
Organoids are cell-derived, 3D in vitro models that are cultured to recapitulate structural and functional aspects of the in vivo tissue they are intended to represent. Organoids are not new to research labs, although there has been much hype about them in recent...
Cell of the Month: Pericytes
It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for normal brain function and development. Which cell type is it? Well,...
The Promises and Problems with ADCs
Antibody drug conjugates (ADCs) are targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. In contrast to conventional chemotherapies, which do not discriminate between healthy and cancerous cells, ADCs are...
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