Models for 10,000 Human Diseases

Better Blood Brain Barrier Models Are Urgently Needed for Modern Therapeutic Advances

Welcome to Part 4 of our series about the blood brain barrier (BBB)! Here, we highlight the rising global burden of neurological disorders, and recap on the challenges surrounding drug safety and toxicity in relation to the BBB. As industry speeds ahead with novel therapeutic approaches to neurological and non-neurological diseases, such as adeno-associated virus (AAV)-based gene therapies, CAR-T cell therapies, and gene-editing therapies, the need to understand safety and toxicity in relation to BBB penetration has never been more urgent.  According to a report published by the World Health Organization (WHO), up to one billion people worldwide were affected by a neurological...

Tempo-iKidneyPod™: Modeling with Microfluidics

Tempo-iKidneyPod™ was mentioned in in a review article that summarized various investigative methods and applications of microfluidic chips, specifically to examine how SARS-CoV-2 causes acute kidney injury (AKI). Tempo-iKidneyPod™ is composed of human...

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In Vitro Blood Brain Barrier Models for Drug Development

Welcome back to our blog series about the blood brain barrier (BBB). In Part 1, we provided a brief history on the discovery of the BBB, and introduced what we currently know about its composition and biological functions. In Part 2, we explain why reliable BBB models...

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Tempo-iMG™ and Tempo-iOligo™: Two New Puzzle Pieces

Tempo-iMG™ and Tempo-iOligo™ were cited by scientists in a study where they built a 3D in vitro organoid model of the blood brain barrier (BBB). They chose to build their BBB model based on a composition of multiple neural and glial cell types. By utilizing...

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