Biomarkers: What Does the Data Really Tell Us?
Biomarker measurements provide valuable information about biological processes, disease and treatment response, but they represent selected features of a much more complex biological system. Many biomarker assays provide a time-fixed snapshot. DNA, RNA and protein...
Immuno-qPCR: Has This Ultrasensitive Biomarker Assay Been Forgotten?
Key Takeaways Overcoming Sample Constraints: Traditional assays like ELISA often struggle with ultra-low volume samples or low-abundance secreted biomarkers. The Power of Signal Amplification: Immuno-qPCR (qIPCR) links antibody specificity to DNA barcode...
Beyond Drug Development: Human Cell-Based NAMs for Chemical Safety Assessment
Welcome back to our series on NAMs. So far, we have looked at how model choice depends on the scientific question, and where NAMs can support nonclinical drug development. In this article, we move beyond pharmaceuticals to look at how human cell-based NAMs could also...
Where Do NAMs Fit in Drug Development?
In our last article, we explored how selecting the right model depends on the scientific question and the stage of research. We summarized the strengths and limitations of animal- and human-derived cells and discussed why moving toward more human-relevant models is...
The Right Model at the Right Time for the Right Scientific Question
It is no secret that cell-based models are the backbone of modern drug discovery. For decades, researchers have used animal-based models including cells and whole animals to investigate mechanisms of disease, screen compounds, and support preclinical research. Over...
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