Chips and Beyond: The Attraction of 3D Organoid Models in Drug Discovery
A critical prerequisite for any drug discovery program is the availability of robust ways to study the disease in question and evaluate how experimental treatments impact disease phenotypes. Disease models ranging from patient-derived cell lines to whole animal models...
Explore Further: More on Human Podocytes and Proximal Tubules
In a previous Cell of The Month article, we explored the biology of the kidney. We highlighted the structure and function of the glomerulus podocytes and proximal tubules; these are specialized cell types found in the nephron, which is the kidney’s key structural and...
iPSC Culture: What Every Researcher Needs to Know
Induced pluripotent stem cells (iPSCs) have become a mainstay in disease modeling and drug development, offering almost unlimited opportunities to study human biology in the lab. However, working with these cells can present hurdles that catch even the most seasoned...
Cell of the Month – Kupffer Cells
Welcome back to our Cell of the Month series! This time, we are talking about Kupffer cells - what they are, what they do, and why we should want to learn more about them! Kupffer cells - the gatekeepers of the liver First described by German anatomist Karl Wilhelm...
The Forgotten Process – Trogocytosis!
Trogocytosis, from trogo meaning ‘to gnaw’ or ‘to nibble’ in Ancient Greek, is an active process during which one cell receives cell surface molecules and membrane fragments from another cell in a unidirectional and cell-contact dependent manner. Within immune cells,...
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