Models for 10,000 Human Diseases

Culturing and Characterising Organoids – What Do We Need to Know?

Organoids are cell-derived, 3D in vitro models that are cultured to recapitulate structural and functional aspects of the in vivo tissue they are intended to represent. Organoids are not new to research labs, although there has been much hype about them in recent years, given their vast and largely untapped potential to reveal novel insights about biological processes and disease mechanisms, as well as serve as models for drug discovery and development, including drug target identification and validation as well as pre-clinical toxicity and efficacy studies.  In previous articles, we looked at the history of organoids, and outlined the typical workflow for their development from...

Cell of the Month: Pericytes

It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for normal brain function and development. Which cell type is it? Well,...

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The Promises and Problems with ADCs

Antibody drug conjugates (ADCs) are targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. In contrast to conventional chemotherapies, which do not discriminate between healthy and cancerous cells, ADCs are...

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Cell of the Month: Liver Sinusoidal Endothelial Cells

Liver sinusoidal endothelial cells (LSECs) are highly specialized liver endothelial cells that form a physical barrier between the blood and hepatocytes. They are the most abundant non-parenchymal hepatic cell population. LSECs play an important role in physiological,...

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On Demand Custom Engineered Cell Models

Tempo develops patient relevant stem cell (iPSCs) based models to support drug discovery, preclinical studies, and early-stage clinical development.