Models for 10,000 Human Diseases

Welcome to Part 3 of our blog series covering the blood brain barrier (BBB). In Part 1, we looked briefly at how the BBB was discovered and presented what we currently know about its composition and functions. Part 2 focused on the need for reliable BBB models in drug development and summarized the current in vitro models. In Part 3, we will look at considerations surrounding the cell types and sources used in in vitro BBB models.  In vitro models that accurately represent the human BBB are a critical part of the developmental process for central nervous system (CNS) drugs, as well as to understand diseases that involve degradation or dysfunction of the BBB. More than a century...