Models for 10,000 Human Diseases

Sources of cells for modeling the human BBB — 4 considerations

Welcome to Part 3 of our blog series covering the blood brain barrier (BBB). In Part 1, we looked briefly at how the BBB was discovered and presented what we currently know about its composition and functions. Part 2 focused on the need for reliable BBB models in drug development and summarized the current in vitro models. In Part 3, we will look at considerations surrounding the cell types and sources used in in vitro BBB models.  In vitro models that accurately represent the human BBB are a critical part of the developmental process for central nervous system (CNS) drugs, as well as to understand diseases that involve degradation or dysfunction of the BBB. More than a century...

In Vitro Blood Brain Barrier Models for Drug Development

Welcome back to our blog series about the blood brain barrier (BBB). In Part 1, we provided a brief history on the discovery of the BBB, and introduced what we currently know about its composition and biological functions. In Part 2, we explain why reliable BBB models...

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Tempo-iMG™ and Tempo-iOligo™: Two New Puzzle Pieces

Tempo-iMG™ and Tempo-iOligo™ were cited by scientists in a nature.com study where they built a 3D in vitro organoid model of the blood brain barrier (BBB). They chose to build their BBB model based on a composition of multiple neural and glial cell types. By utilizing...

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What is the Blood Brain Barrier? Part 1 of a Series

Welcome to our new blog series about the blood brain barrier (BBB)! In Part 1, we will give a brief history on the discovery of the BBB, as well as introduce what we know about its composition and biological functions. The blood brain barrier or BBB is a highly...

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Tempo-iMG™: Targeting Solutions for HIV

Tempo-iMG™, human iPSC-derived microglia, was used in a follow-up study cited in plos.org. This study expanded on a previous discovery showing that healthy microglia were able to silence HIV.  Citation Summary In the current study, scientists from Case Western Reserve...

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On Demand Custom Engineered Cell Models

Tempo develops patient relevant stem cell (iPSCs) based models to support drug discovery, preclinical studies, and early-stage clinical development.