Models for 10,000 Human Diseases

Tempo-iMG™: Architectural Strategies

Tempo-iMG™ was cited in in a study that investigated HIV-1 integration in the unexplored microglia reservoir that gives rise to continued HIV replication in infected cells. Scientists used Tempo-iMG™ human iPSC-derived microglia to determine that CTCF, an architectural chromosomal protein, contributes to the viral integration and latency and is found proximally to topologically associated domains (TAD) within H3K36me3-enriched areas. The authors of the article cited Tempo-iMG™ as an accurate, patient-relevant human model that can be used to represent microglial HIV-infections in the human central nervous system. Citation Summary In this citation, researchers investigated...

Tempo-iKidneyPod™: Modeling with Microfluidics

Tempo-iKidneyPod™ was mentioned in in a review article that summarized various investigative methods and applications of microfluidic chips, specifically to examine how SARS-CoV-2 causes acute kidney injury (AKI). Tempo-iKidneyPod™ is composed of human...

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Disease Models and Assay Services

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On Demand Custom Engineered Cell Models

Tempo develops patient relevant stem cell (iPSCs) based models to support drug discovery, preclinical studies, and early-stage clinical development.