Models for 10,000 Human Diseases

In our last article, we introduced mast cells, their origins and morphology, and summarized how they are activated during IgE-mediated allergic responses. Here, we shift gears and explore how mast cells, together with microglia and the blood brain barrier, contribute to inflammation in the central nervous system. After a quick recap on microglia and the blood brain barrier, we will summarize what is currently understood about their roles in central nervous system inflammation and touch upon what can happen when neuroinflammation becomes chronic. So, what is neuroinflammation? Inflammation is an ancient yet highly complex immune response to protect tissue, remove harmful material...

Cell of the Month: Mast Cells

Mast cells are tissue-resident immune cells derived from the myeloid lineage, and along with basophils, eosinophils and neutrophils, they belong to the granulocyte family of white blood cells. First discovered and named almost 200 years ago by German pathologist...

Culturing and Characterising Organoids – What Do We Need to Know?

Organoids are cell-derived, 3D in vitro models that are cultured to recapitulate structural and functional aspects of the in vivo tissue they are intended to represent. Organoids are not new to research labs, although there has been much hype about them in recent...

Cell of the Month: Pericytes

It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for normal brain function and development. Which cell type is it? Well,...

The Promises and Problems with ADCs

Antibody drug conjugates (ADCs) are targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. In contrast to conventional chemotherapies, which do not discriminate between healthy and cancerous cells, ADCs are...

CRISPR Screen Identifies Potential New Regulators of Fibrosis in Human Liver Cells

In our last few liver articles, we highlighted the urgent need for new models and treatments for non-alcoholic steatohepatitis (NASH), and looked at the potential for human liver organoids to not only model disease, but also to test new drugs for safety and efficacy....

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