Models for 10,000 Human Diseases

Antibody drug conjugates (ADCs) are targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. In contrast to conventional chemotherapies, which do not discriminate between healthy and cancerous cells, ADCs are designed to deliver cytotoxic drugs directly to tumors and are therefore considered to be a more efficacious and safer therapeutic option. In this article, we comment on the progress as well as the safety and efficacy challenges associated with ADC development. Firstly, how do ADCs work? ADCs (have been)  described as the magic bullets of cancer treatment, because they combine the specific targeting ability of...