Human iPSC-derived Dopaminergic Neurons

Tempo-iDopaNer™

Human iPSC-derived Dopaminergic Neurons

Dopaminergic neurons belong to one of the most important neuronal subtypes in the human central nervous system (CNS). In the CNS, these neurons are primarily responsible for transmitting dopamine and they form networks that are responsible for a variety of functions in the substantia nigra, ventral tegmental area, hypothalamus, and zona incerta. They are implicated in many disabling neurological disorders, including Parkinson’s, drug addiction, psychosis, and Attention Deficit Hyperactivity Disorder (ADHD).

Tempo’s iDopaNer™: human dopaminergic neurons are derived from human dermal cells, using integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction and maturation conditions. Tempo’s iDopaNer™ cells are branched structures when plated as a monolayer in culture and express biomarkers such as beta3-Tuj (neuronal), tyrosine hydroxylase (TH), and dopamine transporter (DAT). iDopaNer™ can be used under maturation conditions, co-culture conditions (with astrocytes or additional neuronal subtypes), and short-term functional characterization studies

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