Culturing and Characterising Organoids – What Do We Need to Know?
Organoids are cell-derived, 3D in vitro models that are cultured to recapitulate structural and functional aspects of the in vivo tissue they are intended to represent. Organoids are not new to...
The Promises and Problems with ADCs
Antibody drug conjugates (ADCs) are targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. In contrast to conventional chemotherapies,...
Better Blood Brain Barrier Models Are Urgently Needed for Modern Therapeutic Advances
Welcome to Part 4 of our series about the blood brain barrier (BBB)! Here, we highlight the rising global burden of neurological disorders, and recap on the challenges surrounding drug safety and...
Sources of cells for modeling the human BBB — 4 considerations
Welcome to Part 3 of our blog series covering the blood brain barrier (BBB). In Part 1, we looked briefly at how the BBB was discovered and presented what we currently know about its composition and...
In Vitro Blood Brain Barrier Models for Drug Development
Welcome back to our blog series about the blood brain barrier (BBB). In Part 1, we provided a brief history on the discovery of the BBB, and introduced what we currently know about its composition...
What is the Blood Brain Barrier? Part 1 of a Series
Welcome to our new blog series about the blood brain barrier (BBB)! In Part 1, we will give a brief history on the discovery of the BBB, as well as introduce what we know about its composition and...
The Challenges In Small Molecule Drug Development – Part 3 of our Drug Discoveries Series: To Zs and Z’
Welcome back to the drug discovery series! In this post, we journey through target validation and assay development and validation for compound screening! Target Validation As mentioned earlier in...
Genetically Encoded Biosensors for Research and Drug Discovery
Genetically Encoded Biosensors for Research and Drug Discovery Mitochondrial integrity and function are pivotal to cellular energy production, and mitochondrial dysfunction has been shown to alter...
The Lowdown on Transcriptional Reporters
Gene reporter assays have contributed hugely to our understanding of how genes are regulated during growth and development, for example, through the study of spatiotemporal gene expression patterns,...