Sources of cells for modeling the human BBB — 4 considerations
Welcome to Part 3 of our blog series covering the blood brain barrier (BBB). In Part 1, we looked briefly at how the BBB was discovered and presented what we currently know about its composition and...
In Vitro Blood Brain Barrier Models for Drug Development
Welcome back to our blog series about the blood brain barrier (BBB). In Part 1, we provided a brief history on the discovery of the BBB, and introduced what we currently know about its composition...
What is the Blood Brain Barrier? Part 1 of a Series
Welcome to our new blog series about the blood brain barrier (BBB)! In Part 1, we will give a brief history on the discovery of the BBB, as well as introduce what we know about its composition and...
The Challenges In Small Molecule Drug Development – Part 3 of our Drug Discoveries Series: To Zs and Z’
Welcome back to the drug discovery series! In this post, we journey through target validation and assay development and validation for compound screening! Target Validation As mentioned earlier in...
Genetically Encoded Biosensors for Research and Drug Discovery
Genetically Encoded Biosensors for Research and Drug Discovery Mitochondrial integrity and function are pivotal to cellular energy production, and mitochondrial dysfunction has been shown to alter...
The Lowdown on Transcriptional Reporters
Gene reporter assays have contributed hugely to our understanding of how genes are regulated during growth and development, for example, through the study of spatiotemporal gene expression patterns,...
The Challenges In Small Molecule Drug Development – Part 2: Target Identification
Welcome back to our small molecule drug development series! If you’re only joining us now, check out our introductory article to drug discovery. Otherwise let’s dive straight into the world of drug...
The Challenges In Small Molecule Drug Development – Part I
The world of drug discovery is rife with new approaches within immunotherapy (e.g., T cell-based cancer therapies), personalized vaccines, microbiome therapies, and CRISPR-based therapies in an...
Providing the Right Cues for Organoid Development
Organoids are in vitro-derived miniaturized organs that exhibit self-organization and recapitulate the functions of the in vivo organ they represent. For organoids to mimic their real-life...