TempoStemBank™
Disease Models and iPSC derivative Cell Types
Applications
TempoStemBank™ are intended for basic scientific research, drug discovery and therapeutics development use only. It is not a product for human testing or diagnostics.
Disease modeling and drug discovery
Developmental and lineage differentiation studies
Scalable for BioBanking (cGMP-grade possible)
High Content Screening (e.g., phenotypic assays for preclinical drug development)
Disease Models
Frequently Requested Disease Models for iPSC lines or iPS-derived cell types in the ectoderm, endoderm, and mesenchymal lineages:
- Frontotemporal Dementia (FTD)
- Familial Alzheimer’s Disease (FAD; early onset; late onset)
- Parkinson’s Disorder (PD)
- Multiple Sclerosis (MS)
- Seizure Disorders (e.g., Epilepsy)
- Motor Neuron Diseases (e.g., ALS, PLS)
- Duchenne Muscular Dystrophy (DMD)
- Spinal Muscular Atrophy (SMA Types I-IV)
- Friedreich’s Ataxia
- Cardiomyopathy (e.g., Fabry Disease, Primary arrhythmias)
- Muscular Dystrophy with Early Contractures and Cardiomyopathy
- Emery-Dreifuss Muscular Dystrophy (EDMD)
- Osteogenesis Imperfecta
- Tourette Syndrome
- Ataxia-Telangiectasia
- Huntington Disease
- Williams Syndrome
- Spinocerebellar Ataxia
- Warfan Syndrome
- Affective Disorders (e.g., Bipolar Disorder, Depression.)
- Schizophrenia
- Sensory Neuropathy
- Diabetes (Types: Familial, Juvenile Onset, or Maturity Onset)
- Fragile X Syndrome
- Fabry Disease
- Angelman’s Syndrome
- Trisomy 21 (Down Syndrome)
- Turner Syndrome
- Sickle Cell Anemia (& carriers)
- Turcot Syndrome
- Osteoporosis
- Paget Disease of Bone
- Rheumatoid arthritis
- Bernard-Soulier Syndrome (Giant Platelet Syndrome)
- Von Hippel-Lindau Syndrome (VHL)
- Chronic Kidney Diseases
- Prader-Willi Syndrome (PWS)
- Charcot-Marie-Tooth Disease
- Cancer iPSCs (e.g., osteosarcoma, ovarian tumors, colorectal, neuroblastoma, glioblastoma multiforme (GBM), renal cell carcinoma (RCC), head-and-neck)
- Ethnically Diverse Donors’ Derived iPSCs
Citations
- Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple Sclerosis.
- The Genetic Multiple Sclerosis (MS) Risk Variant rs7665090-G Increases Astrocyte Responses and Lymphocyte Recruitment to White Matter Lesions.
- Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling
- Cell Sources and Methods for Producing Organotypic in vitro Human Tissue Models
- Probing Prodrug Metabolism and Reciprocal Toxicity with an Integrated and Humanized Multi-Tissue Organ-on-a-Chip Platform
- Cross-talk between microglia and neurons regulates HIV latency
- Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction
- Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model
- Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response.
- βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity.
- Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
- Advanced In Vitro Lung Models for Drug and Toxicity Screening: The Promising Role of Induced Pluripotent Stem Cells
- Genomic Profiling of HIV-1 Integration in microglia cells links viral integration to the topologically associated domains.
- Generation of Oligodendrocytes from Human Pluripotent and Embryonic Stem Cells.
- TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
- Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies
- Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells
- Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity
- Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration
- A revolutionary breakthrough of bionanomaterials in tissue engineering and regenerative medicine
- Modeling Multiple Sclerosis with hiPSC-derived Astrocytes
- Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions