Tempo Bioscience Expands Human Liver Models for Toxicity Evaluation and Disease Modeling

Mar 15, 2023 | News

SAN FRANCISCO, CA —Tempo Bioscience, Inc. (“Tempo”) a privately-held biotechnology company based in San Francisco, California, has released new human induced pluripotent stem cell (iPSC) derived cell products and affiliated cell-based services in the following categories:

Tempo-iHepStellate™ – Human iPSC-derived Hepatic Stellate Cells
Tempo-iKupffer – Human iPSC-derived Kupffer Cells
Tempo-iLSEC™ – Human iPSC-derived Liver Sinusoidal Endothelial Cells
Tempo-iHep3D – Human iPSC-derived Hepatocytes

Together, Tempo-iHepStellate-iKupffer-iLSEC-iHep3D form human liver organoids for modeling diseases such as Nonalcoholic Steatohepatitis (NASH), Nonalcoholic fatty liver disease (NAFLD), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). As 3D structures, Tempo-iHep3D spheroids overcome challenges of modeling long-term (25 days or more) drug induced toxicity in vitro. Derivative cell types from human iPSCs offer purity of genetic materials, human relevance, and robust patient matched models. These new products add to the already-existing Tempo Bioscience product lines and expand the TempoStemBankDisease Model offerings. Currently, more than twenty-five iPSC-derivative cell types are offered to create patient-relevant disease models. Each cell type can be manufactured at scale for a variety of drug discovery and development applications. 

Tempo Bioscience is the sole manufacturer of human iPSC-derived cell types that are engineered using non-viral, nucleic-acids-free, serum-free, and feeder-free technologies. Tempo is committed to advancing technologies that focus on disease modeling and drug safety evaluations using advanced human iPSC-derived cell models in 2D, as well as in 3D as spheroids or organoids. Tempo’s patient-relevant cell models aim to improve drug efficacy evaluations and safety assessments during drug development.

About Tempo Bioscience, Inc.: Tempo is a technology development focused biotechnology company based in San Francisco, California. Tempo develops and manufactures human iPSC-based biosensor enabling technologies for the biotech, pharmaceutical, and consumer product industries. For more information on Tempo, please visit our home page: https://www.tempobioscience.com. Follow us on LinkedIn.

Tempo Bioscience, Inc
Angela L. Huang PhD ; 650-731-5620