Models for 10,000 Human Diseases

Sources of cells for modeling the human BBB — 4 considerations

Welcome to Part 3 of our blog series covering the blood brain barrier (BBB). In Part 1, we looked briefly at how the BBB was discovered and presented what we currently know about its composition and functions. Part 2 focused on the need for reliable BBB models in drug development and summarized the current in vitro models. In Part 3, we will look at considerations surrounding the cell types and sources used in in vitro BBB models.  In vitro models that accurately represent the human BBB are a critical part of the developmental process for central nervous system (CNS) drugs, as well as to understand diseases that involve degradation or dysfunction of the BBB. More than a century...

Cell of the Month: Vascular Endothelial Cells

Vascular endothelium is a thin monolayer of cells that constitute the lining of blood vessels and organs (1-3). A hallmark of many diseases (e.g., cancer, diabetes mellitus, viral infections, etc) is highlighted in the dysfunctional states of the vascular endothelium....

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Cell of the Month: Cardiomyocytes

Cardiomyocytes are cardiac muscle cells. They are terminally differentiated and facilitate contractile forces ("beatings") of the heart. Grown in vitro as a monolayer sheath, cardiomyocytes are connected by gap junction proteins that help synchronize...

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Cell of the Month: CD34+ Cells

Welcome back to our cell of the month series. This time we’re talking about CD34+ cells, a type of undifferentiated multipotent hematopoetic stem cell (HSC) with the potential to differentiate into almost any other blood cell type under specific conditions. As stem...

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Cell of the Month: The Kidney

Most of us will remember from high school biology class that kidneys comprise part of the excretory system and function in toxin removal, maintaining electrolyte homeostasis and regulating the body’s acid-base balance. Beyond this, proper kidney function is also...

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