Models for 10,000 Human Diseases

Culturing and Characterising Organoids – What Do We Need to Know?

Organoids are cell-derived, 3D in vitro models that are cultured to recapitulate structural and functional aspects of the in vivo tissue they are intended to represent. Organoids are not new to research labs, although there has been much hype about them in recent years, given their vast and largely untapped potential to reveal novel insights about biological processes and disease mechanisms, as well as serve as models for drug discovery and development, including drug target identification and validation as well as pre-clinical toxicity and efficacy studies.  In previous articles, we looked at the history of organoids, and outlined the typical workflow for their development from...

In Vitro Blood Brain Barrier Models for Drug Development

Welcome back to our blog series about the blood brain barrier (BBB). In Part 1, we provided a brief history on the discovery of the BBB, and introduced what we currently know about its composition and biological functions. In Part 2, we explain why reliable BBB models...

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Tempo-iMG™ and Tempo-iOligo™: Two New Puzzle Pieces

Tempo-iMG™ and Tempo-iOligo™ were cited by scientists in a nature.com study where they built a 3D in vitro organoid model of the blood brain barrier (BBB). They chose to build their BBB model based on a composition of multiple neural and glial cell types. By utilizing...

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What is the Blood Brain Barrier? Part 1 of a Series

Welcome to our new blog series about the blood brain barrier (BBB)! In Part 1, we will give a brief history on the discovery of the BBB, as well as introduce what we know about its composition and biological functions. The blood brain barrier or BBB is a highly...

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Tempo-iMG™: Targeting Solutions for HIV

Tempo-iMG™, human iPSC-derived microglia, was used in a follow-up study cited in plos.org. This study expanded on a previous discovery showing that healthy microglia were able to silence HIV.  Citation Summary In the current study, scientists from Case Western Reserve...

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Tempo Bioscience Services

Disease Models and Assay Services

Tempo offers services and alliances based on our advanced technological platforms and a range of capabilities. Our team differentiates ourselves based on a strong commitment to innovative solutions and quality R&D for our partners.

Tempo Bioscience Support

On Demand Custom Engineered Cell Models

Tempo develops patient relevant stem cell (iPSCs) based models to support drug discovery, preclinical studies, and early-stage clinical development.