Models for 10,000 Human Diseases

In our last article, we introduced mast cells, their origins and morphology, and summarized how they are activated during IgE-mediated allergic responses. Here, we shift gears and explore how mast cells, together with microglia and the blood brain barrier, contribute to inflammation in the central nervous system. After a quick recap on microglia and the blood brain barrier, we will summarize what is currently understood about their roles in central nervous system inflammation and touch upon what can happen when neuroinflammation becomes chronic. So, what is neuroinflammation? Inflammation is an ancient yet highly complex immune response to protect tissue, remove harmful material...