by Karen O'Hanlon Cohrt | May 27, 2024 | Disease Models
Mast cells are tissue-resident immune cells derived from the myeloid lineage, and along with basophils, eosinophils and neutrophils, they belong to the granulocyte family of white blood cells. First discovered and named almost 200 years ago by German pathologist...
by Karen O'Hanlon Cohrt | Apr 4, 2023 | Disease Models
This article was originally published on 4th April 2023. It was revised and republished on 19th March 2023, to reflect important updates in the NASH therapeutic development space, including FDA approval of Rezdiffra in March 2024. Welcome to our new mini-series about...
by Karen O'Hanlon Cohrt | Dec 26, 2023 | Disease Models
It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for normal brain function and development. Which cell type is it? Well,...
by Olwen Reina | Jul 26, 2016 | Disease Models
Melanocytes are cells that produce melanin, the pigment present in our skin, eyes, and hair. iPS-derived melanocytes are used in models of skin disease, drug toxicity assays, skin bioprinting and in cell therapy R&D. Previously, we looked at the role of melanin...
by Olwen Reina | Jul 10, 2016 | Disease Models
Melanocytes are melanin-producing cells found mainly in the lowest part of the top layer of your skin or to put it in science-speak: the stratum basale of your epidermis (see our article on the morphology of the skin). Melanin is a pigment, best known and primarily...
by Allison Kennedy | Jun 26, 2023 | Disease Models
Liver sinusoidal endothelial cells (LSECs) are highly specialized liver endothelial cells that form a physical barrier between the blood and hepatocytes. They are the most abundant non-parenchymal hepatic cell population. LSECs play an important role in physiological,...
