iPSC Culture: What Every Researcher Needs to Know

by Karen O'Hanlon Cohrt | Feb 4, 2025 | Cell Culture Techniques, Trends

Induced pluripotent stem cells (iPSCs) have become a mainstay in disease modeling and drug development, offering almost unlimited opportunities to study human biology in the lab. However, working with these cells can present hurdles that catch even the most seasoned...

Chips and Beyond: The Attraction of 3D Organoid Models in Drug Discovery

by Karen O'Hanlon Cohrt | Jun 8, 2025 | Cell Culture Techniques, Trends

A critical prerequisite for any drug discovery program is the availability of robust ways to study the disease in question and evaluate how experimental treatments impact disease phenotypes. Disease models ranging from patient-derived cell lines to whole animal models...

Tempo-iOligo™: Major study identifies TMEFF1 as a critical factor for HSV-1 replication in the central nervous system

by Karen O'Hanlon Cohrt | Sep 24, 2024 | Citation Alerts

Tempo-iOligo™was cited in Nature in a major infectious disease study that offers the first explanation as to why herpes simplex virus 1 (HSV-1) infection in the brain is very rare, despite the fact that most of us have been infected with the virus. The study used...

Blood Brain Barrier and Inflammatory Cell Types in the Human CNS

by Karen O'Hanlon Cohrt | Jul 24, 2024 | Trends

In our last article, we introduced mast cells, their origins and morphology, and summarized how they are activated during IgE-mediated allergic responses. Here, we shift gears and explore how mast cells, together with microglia and the blood brain barrier, contribute...

Culturing and Characterising Organoids – What Do We Need to Know?

by Karen O'Hanlon Cohrt | Feb 18, 2024 | Trends

Organoids are cell-derived, 3D in vitro models that are cultured to recapitulate structural and functional aspects of the in vivo tissue they are intended to represent. Organoids are not new to research labs, although there has been much hype about them in recent...