Immuno-qPCR: Has This Ultrasensitive Biomarker Assay Been Forgotten?
Key Takeaways Overcoming Sample Constraints: Traditional assays like ELISA often struggle with ultra-low volume samples or low-abundance secreted biomarkers. The Power of Signal Amplification:...
Beyond Drug Development: Human Cell-Based NAMs for Chemical Safety Assessment
Welcome back to our series on NAMs. So far, we have looked at how model choice depends on the scientific question, and where NAMs can support nonclinical drug development. In this article, we move...
Where Do NAMs Fit in Drug Development?
In our last article, we explored how selecting the right model depends on the scientific question and the stage of research. We summarized the strengths and limitations of animal- and human-derived...
The Right Model at the Right Time for the Right Scientific Question
It is no secret that cell-based models are the backbone of modern drug discovery. For decades, researchers have used animal-based models including cells and whole animals to investigate mechanisms...
Why and How Do We Study Keratinocytes?
In a previous article we introduced keratinocytes and looked at their biological functions and subtypes. Here, we explore some of the main reasons researchers study keratinocytes and the various...
Chips and Beyond: The Attraction of 3D Organoid Models in Drug Discovery
A critical prerequisite for any drug discovery program is the availability of robust ways to study the disease in question and evaluate how experimental treatments impact disease phenotypes. Disease...
iPSC Culture: What Every Researcher Needs to Know
Induced pluripotent stem cells (iPSCs) have become a mainstay in disease modeling and drug development, offering almost unlimited opportunities to study human biology in the lab. However, working...
The Forgotten Process – Trogocytosis!
Trogocytosis, from trogo meaning ‘to gnaw’ or ‘to nibble’ in Ancient Greek, is an active process during which one cell receives cell surface molecules and membrane fragments from another cell in a...
Blood Brain Barrier and Inflammatory Cell Types in the Human CNS
In our last article, we introduced mast cells, their origins and morphology, and summarized how they are activated during IgE-mediated allergic responses. Here, we shift gears and explore how mast...