Human Liver Organoids as a New Model for Non-Alcoholic Fatty Liver Disease
The lack of approved treatments for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatosis (NASH) is largely explained by the shortcomings of cellular models used to unravel disease...
Cell of the Month: Liver Sinusoidal Endothelial Cells
Liver sinusoidal endothelial cells (LSECs) are highly specialized liver endothelial cells that form a physical barrier between the blood and hepatocytes. They are the most abundant non-parenchymal...
NASH – The Urgent Need for Better Disease Models and New Therapies
This article was originally published on 4th April 2023. It was revised and republished on 19th March 2023, to reflect important updates in the NASH therapeutic development space, including FDA...
Cell of the Month: Cells in a 3D Spheroid
Spheroids have been used in cell culture for decades. In the 1980s, different types of human cancer cells --normally grown as monolayers or suspension cultures--were tested for their innate...
Cell of the Month: Vascular Endothelial Cells
Vascular endothelium is a thin monolayer of cells that constitute the lining of blood vessels and organs (1-3). A hallmark of many diseases (e.g., cancer, diabetes mellitus, viral infections, etc)...
Cell of the Month: Cardiomyocytes
Cardiomyocytes are cardiac muscle cells. They are terminally differentiated and facilitate contractile forces ("beatings") of the heart. Grown in vitro as a monolayer sheath, cardiomyocytes are...
Cell of the Month: CD34+ Cells
Welcome back to our cell of the month series. This time we’re talking about CD34+ cells, a type of undifferentiated multipotent hematopoetic stem cell (HSC) with the potential to differentiate into...
Cell of the Month: The Kidney
Most of us will remember from high school biology class that kidneys comprise part of the excretory system and function in toxin removal, maintaining electrolyte homeostasis and regulating the...
Cell of the Month: Osteoblasts
Cell of The Month: Osteoblasts Osteoblasts, often referred to as bone-forming cells, are specialized and terminally differentiated products of mesenchymal stem cells whose major function is to...