How Do Transwell and TEER Assays Help Us Understand Biological Barrier Function?
How do Transwell assays help model biological barriers in the lab? What does TEER tell us about barrier integrity and tight-junction strength? How can these assays advance our understanding of drug...
Why and How Do We Study Keratinocytes?
In a previous article we introduced keratinocytes and looked at their biological functions and subtypes. Here, we explore some of the main reasons researchers study keratinocytes and the various...
2D vs 3D Cell Culture: Choosing the Right Model for Disease Research
In our last article, we compared 2D organ-on-a-chip devices and 3D organoids with respect to their use in drug discovery, highlighting their importance in modeling diseases and evaluating efficacy...
Explore Further: More on Human Podocytes and Proximal Tubules
In a previous Cell of The Month article, we explored the biology of the kidney. We highlighted the structure and function of the glomerulus podocytes and proximal tubules; these are specialized cell...
Cell of the Month – Kupffer Cells
Welcome back to our Cell of the Month series! This time, we are talking about Kupffer cells - what they are, what they do, and why we should want to learn more about them! Kupffer cells - the...
Cell of the Month: Mast Cells
Mast cells are tissue-resident immune cells derived from the myeloid lineage, and along with basophils, eosinophils and neutrophils, they belong to the granulocyte family of white blood cells. ...
Cell of the Month: Pericytes
It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for...
CRISPR Screen Identifies Potential New Regulators of Fibrosis in Human Liver Cells
In our last few liver articles, we highlighted the urgent need for new models and treatments for non-alcoholic steatohepatitis (NASH), and looked at the potential for human liver organoids to not...
Human Liver Organoids as a New Model for Non-Alcoholic Fatty Liver Disease
The lack of approved treatments for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatosis (NASH) is largely explained by the shortcomings of cellular models used to unravel disease...