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Tempo-iRPE™: human iPS-derived retinal pigment epithelial cells

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$675.00
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Summary

Retinal pigment epithelium (RPE) is the pigmented cell layer surrounding the neurosensory retina. The cells support the retinal visual cells, and they are attached to the underlying choroid and overlying retinal visual cells. The RPE has several functions: light absorption, epithelial transport, spatial ion buffering, visual cycle, phagocytosis, secretion and immune modulation. Tempo-iRPETM are human iPS-derived retinal pigment epithelial cells. They express biomarkers such as RPE-65, RLBP1, and BEST.


Academic scientists receive a special rate!

Tempo-iRPE; immunocytochemistry, anti-human-RPE65 (ThermoFisher)

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  • Tempo-iRPE; contrast image; monolayer
  • Tempo-iRPE; RT-PCR data (left-to-right; 2 lanes/gene): RLBP1, RPE65, BEST.

Details

Retinal pigment epithelium (RPE) is the pigmented cell layer surrounding the neurosensory retina. The cells support the retinal photoreceptor cells, and they are attached to the underlying choroid and overlying retinal visual cells. The RPE has several functions: light absorption, epithelial transport, spatial ion buffering, visual cycle, phagocytosis, secretion and immune modulation.  The RPE is comprised of hexagonal cells organized into a densely packed monolayer. The RPE is of the neuroectodermal origin.

Tempo-iRPETM are human iPS-derived retinal pigment epithelial cells. They express biomarkers (e.g., RPE-65, RLBP1, and BEST). They grow as a monolayer and show abilities to phagocytose. The iRPEs play a critical role in functionally support the photoreceptors. They are valuable tools for studying age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, photoreceptor degeneration, gene expression, phagocytosis, and cellular interactions.

Applications:

  • Disease modeling
  • Toxicity testing
  • Phenotypic Screening (e.g., cytokine secretion, expression of differentiation markers)
  • In vitro assays using RPE cells

Academic scientists receive a special rate!

Specifications: ~0.9 x10^6 cells per 1ml of freezing medium (vial)

Long-term Storage: liquid nitrogen

Growth Properties: adherent monolayer

Starting Materials: human dermal/fibroblast cells were reprogrammed using a proprietary foot-print-free technology.

Storage: remove cryovials (dry ice packaging) and place the vial into liquid nitrogen for storage. Alternatively, thaw and use the cells immediately.

QC: Sterility, Safety, HIV/viruses, bacteria, fungi: negative, Cell viability post-thawing (>90%)

SKU210

Additional Information

Product Use Tempo-iRPE™ are intended for basic scientific research and drug discovery use only. It is not a product for human testing or diagnostics.