Tag : stem cells

The remarkable propensity of mesenchymal stem cells (MSCs) for self-renewal, multi-lineage differentiation and immune-modulatory activity has attracted much attention within the cell therapy area, from their potential in cell therapies and research models to their emerging role in the fight against cancer.

MSC Properties Are Greatly Influenced by Source

Despite their great potential, MSC-based therapies have not yet made it to the clinic, and a number of challenges must be addressed before their full therapeutic potential can be realized. One major challenge is their lack of uniformity, such that MSCs vary depending on their external and tissue environment, their original tissue source, and the isolation method used.

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Written on Jul, 30, 2018 by in , ,

Cell of The Month: Osteoblasts

Osteoblasts, often referred to as bone-forming cells, are specialized and terminally differentiated products of mesenchymal stem cells whose major function is to synthesize bone in a process known as osteogenesis.

Osteogenesis

During osteogenesis, osteoblasts are organized into closely packed sheets of connected cells on the bone surface, from which cellular processes may extend through the developing bone. Osteoblasts produce and release proteins, hormones, and other materials into their extracellular environment, where they assemble to form a thin layer (approximately 10 µm thick) of flexible bone tissue called an osteoid (also known as the un-mineralized bone matrix) on the surface of a newly developing bone or a bone that is undergoing repair.

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Written on Jul, 02, 2018 by in ,

Organoids are in vitro-derived miniaturized organs that exhibit self-organization and recapitulate the functions of the in vivo organ they represent. For organoids to mimic their real-life counterparts as much as possible, they must receive appropriate physical and biochemical cues. These cues might include:

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