Tag : Personalized Medicine

Written on Jul, 16, 2018 by in ,

The world of drug discovery is rife with new approaches within immunotherapy (e.g., T cell-based cancer therapies), personalized vaccines, microbiome therapies, and CRISPR-based therapies in an attempt to provide novel treatments and cures for a wide range of diseases, most often cancer. Despite the fact that progress is being made in these areas, with FDA-approval granted for the first two CAR T-cell therapies in 2017, more than 90 % of the drugs currently available on the worldwide therapeutics market is comprised of small molecules. This fact is further illustrated by the overwhelming presence of small molecule drugs in the World Health Organization’s Model Lists of Essential Medicines, lists containing “the medications considered to be most effective and safe to meet the most important needs in a health system”.  (more…)

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Written on May, 25, 2018 by in ,

In simple terms, cancer organoids are organoids that are generated from cells donated by cancer patients. In our previous post about organoids, we described their many uses and applications, ranging from disease models, drug and toxicity testing, tissue and organ regeneration, and basic research to improve our understanding of biological processes such as those that govern embryonic development.

When we shift our focus to cancer organoids, it quickly becomes evident that their main applications lie in their potential to shed light on the processes of cancer development and metastasis, to help us understand heterogeneity within tumors via single cell sequencing, and to direct clinicians towards personalized cancer treatments based on patient-specific drug testing.

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Written on Mar, 22, 2018 by in ,

In one of our recent posts, we addressed the types of genetic variability that exist in humans and why a greater understanding of these is critical in diagnostics, for predicting our response to new drugs, and in the development of personalized treatments. Here, we will look at how genetic variability can serve as a tool to expand our understanding of disease susceptibility and mechanisms, using schizophrenia as a case study.

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