Tag : organoids

Written on Dec, 17, 2018 by in ,

The increasing complexity of novel therapies calls for disease models that take us closer than ever before to the in vivo situation, to maximize efficacy and safety evaluations of new experimental treatments. Significant improvements in our understanding of mammalian tissue development, homeostasis, and extracellular matrix biology, coupled with advances in human iPSCs (adult stem cells) and 3D culture have facilitated the generation of organoids and organ-on-a-chip technologies that serve as in vitro 3D models of healthy and diseased mammalian tissue. These technologies aim to become an integral part of research and drug discovery to provide novel insights into biological processes, mechanisms of disease, and responses to drug candidates and other treatments.

Tempo Bioscience attended the World Preclinical Congress Europe in Lisbon last month. This congress centers on preclinical research across a broad disease spectrum, and aims to illuminate the challenges and opportunities within early drug discovery and development. This years program covered topics spanning organ-on-a-chip, 3D cellular models, human induced pluripotent stem cells (hiPSC), and artificial intelligence and machine learning in drug discovery, to name a few. Of particular interest to Tempo Bioscience, the meeting highlighted progress as well as challenges with organs-on-chips, with the latter including scalability and adaption of the technology for applications in the biopharma industry. Here, we round up our top 3 symposium highlights within the organ-on-a-chip space.

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Written on Jul, 02, 2018 by in ,

Organoids are in vitro-derived miniaturized organs that exhibit self-organization and recapitulate the functions of the in vivo organ they represent. For organoids to mimic their real-life counterparts as much as possible, they must receive appropriate physical and biochemical cues. These cues might include:

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Written on May, 25, 2018 by in ,

In simple terms, cancer organoids are organoids that are generated from cells donated by cancer patients. In our previous post about organoids, we described their many uses and applications, ranging from disease models, drug and toxicity testing, tissue and organ regeneration, and basic research to improve our understanding of biological processes such as those that govern embryonic development.

When we shift our focus to cancer organoids, it quickly becomes evident that their main applications lie in their potential to shed light on the processes of cancer development and metastasis, to help us understand heterogeneity within tumors via single cell sequencing, and to direct clinicians towards personalized cancer treatments based on patient-specific drug testing.

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