Category : DrugDiscoverySeries

Written on Oct, 01, 2018 by in ,

Gene reporter assays have contributed hugely to our understanding of how genes are regulated during growth and development, for example, through the study of spatiotemporal gene expression patterns, as well as how gene expression is regulated by transcription factors, gene regulatory elements (so-called cis-acting elements), and exogenous regulators (trans-acting factors). Besides investigating gene regulation, gene reporter assays are also useful in transfection experiments, both to optimize and standardize transfection efficiencies and to screen transfected cells in routine workflows.  (more…)

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Written on Sep, 10, 2018 by in ,

Welcome back to our small molecule drug development series! If you’re only joining us now, check out our introductory article to drug discovery. Otherwise let’s dive straight into the world of drug target identification!

So, What Is a Drug Target?

In the world of drug discovery, target can mean something different depending on whom you ask. It may refer to the intended market for the drug (e.g., developing countries), the therapeutic indications (i.e. what condition(s) the drug is expected to treat), the biological pathway or process that the drug modulates, or the molecular recognition site to which it binds.

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Written on Jul, 16, 2018 by in ,

The world of drug discovery is rife with new approaches within immunotherapy (e.g., T cell-based cancer therapies), personalized vaccines, microbiome therapies, and CRISPR-based therapies in an attempt to provide novel treatments and cures for a wide range of diseases, most often cancer. Despite the fact that progress is being made in these areas, with FDA-approval granted for the first two CAR T-cell therapies in 2017, more than 90 % of the drugs currently available on the worldwide therapeutics market is comprised of small molecules. This fact is further illustrated by the overwhelming presence of small molecule drugs in the World Health Organization’s Model Lists of Essential Medicines, lists containing “the medications considered to be most effective and safe to meet the most important needs in a health system”.  (more…)

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