Category : iPSCs

Written on Dec, 17, 2018 by in ,

The increasing complexity of novel therapies calls for disease models that take us closer than ever before to the in vivo situation, to maximize efficacy and safety evaluations of new experimental treatments. Significant improvements in our understanding of mammalian tissue development, homeostasis, and extracellular matrix biology, coupled with advances in human iPSCs (adult stem cells) and 3D culture have facilitated the generation of organoids and organ-on-a-chip technologies that serve as in vitro 3D models of healthy and diseased mammalian tissue. These technologies aim to become an integral part of research and drug discovery to provide novel insights into biological processes, mechanisms of disease, and responses to drug candidates and other treatments.

Tempo Bioscience attended the World Preclinical Congress Europe in Lisbon last month. This congress centers on preclinical research across a broad disease spectrum, and aims to illuminate the challenges and opportunities within early drug discovery and development. This years program covered topics spanning organ-on-a-chip, 3D cellular models, human induced pluripotent stem cells (hiPSC), and artificial intelligence and machine learning in drug discovery, to name a few. Of particular interest to Tempo Bioscience, the meeting highlighted progress as well as challenges with organs-on-chips, with the latter including scalability and adaption of the technology for applications in the biopharma industry. Here, we round up our top 3 symposium highlights within the organ-on-a-chip space.

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The remarkable propensity of mesenchymal stem cells (MSCs) for self-renewal, multi-lineage differentiation and immune-modulatory activity has attracted much attention within the cell therapy area, from their potential in cell therapies and research models to their emerging role in the fight against cancer.

MSC Properties Are Greatly Influenced by Source

Despite their great potential, MSC-based therapies have not yet made it to the clinic, and a number of challenges must be addressed before their full therapeutic potential can be realized. One major challenge is their lack of uniformity, such that MSCs vary depending on their external and tissue environment, their original tissue source, and the isolation method used.

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Written on Jul, 30, 2018 by in , ,

Cell of The Month: Osteoblasts

Osteoblasts, often referred to as bone-forming cells, are specialized and terminally differentiated products of mesenchymal stem cells whose major function is to synthesize bone in a process known as osteogenesis.

Osteogenesis

During osteogenesis, osteoblasts are organized into closely packed sheets of connected cells on the bone surface, from which cellular processes may extend through the developing bone. Osteoblasts produce and release proteins, hormones, and other materials into their extracellular environment, where they assemble to form a thin layer (approximately 10 µm thick) of flexible bone tissue called an osteoid (also known as the un-mineralized bone matrix) on the surface of a newly developing bone or a bone that is undergoing repair.

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