Monthly Archives: July 2018

Archive of posts published in the specified Month

Written on Jul, 30, 2018 by in , ,

Cell of The Month: Osteoblasts

Osteoblasts, often referred to as bone-forming cells, are specialized and terminally differentiated products of mesenchymal stem cells whose major function is to synthesize bone in a process known as osteogenesis.

Osteogenesis

During osteogenesis, osteoblasts are organized into closely packed sheets of connected cells on the bone surface, from which cellular processes may extend through the developing bone. Osteoblasts produce and release proteins, hormones, and other materials into their extracellular environment, where they assemble to form a thin layer (approximately 10 µm thick) of flexible bone tissue called an osteoid (also known as the un-mineralized bone matrix) on the surface of a newly developing bone or a bone that is undergoing repair.

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Written on Jul, 16, 2018 by in ,

The world of drug discovery is rife with new approaches within immunotherapy (e.g., T cell-based cancer therapies), personalized vaccines, microbiome therapies, and CRISPR-based therapies in an attempt to provide novel treatments and cures for a wide range of diseases, most often cancer. Despite the fact that progress is being made in these areas, with FDA-approval granted for the first two CAR T-cell therapies in 2017, more than 90 % of the drugs currently available on the worldwide therapeutics market is comprised of small molecules. This fact is further illustrated by the overwhelming presence of small molecule drugs in the World Health Organization’s Model Lists of Essential Medicines, lists containing “the medications considered to be most effective and safe to meet the most important needs in a health system”.  (more…)

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Written on Jul, 02, 2018 by in ,

Organoids are in vitro-derived miniaturized organs that exhibit self-organization and recapitulate the functions of the in vivo organ they represent. For organoids to mimic their real-life counterparts as much as possible, they must receive appropriate physical and biochemical cues. These cues might include:

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