January 2019 - Tempo Bioscience

CRISPR Screen Identifies Potential New Regulators of Fibrosis in Human Liver Cells

In our last few liver articles, we highlighted the urgent need for new models and treatments for non-alcoholic steatohepatitis (NASH), and looked at the potential for human liver organoids to...

Human Liver Organoids as a New Model for Non-Alcoholic Fatty Liver Disease

The lack of approved treatments for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatosis (NASH) is largely explained by the shortcomings of cellular models used to unravel...

Cell of the Month: Liver Sinusoidal Endothelial Cells

Liver sinusoidal endothelial cells (LSECs) are highly specialized liver endothelial cells that form a physical barrier between the blood and hepatocytes. They are the most abundant...

The Challenges In Small Molecule Drug Development – Part 3 of our Drug Discoveries Series: To Zs and Z’

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CRISPR Screen Identifies Potential New Regulators of Fibrosis in Human Liver Cells

Human Liver Organoids as a New Model for Non-Alcoholic Fatty Liver Disease

Cell of the Month: Liver Sinusoidal Endothelial Cells