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TempoVol™-iCort: Cationic Voltage Biosensor Assay using Human Cortical Neurons

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$950.00
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Summary

TempoVol™-iCort: cationic voltage biosensor assay using human iPS-derived . They are derived from integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary neural induction and maturation conditions. TempoVol™-iCort cells are polarized structures when plated as a monolayer in culture and express markers such as MAP2 and beta-Tuj. We've validated iCort™ cells to be cationic-conducting neurons when exposed to solutions with fluctuating concentrations of sodium, calcium, potassium, magnesium, and protons/H+. TempoVol™ biosensor is introduced to the cells using proprietary methods and is expressed in the in abundance in the cell.

iPS-derived cortical neurons; ICC using anti-beta-Tuj

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Details

TempoVol™-iCort: cationic voltage biosensor assay using human iPS-derived . They are derived from integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary neural induction and maturation conditions. TempoVol™-iCort cells are polarized structures when plated as a monolayer in culture and express markers such as MAP2 and beta-Tuj. We've validated iCort™ cells to be cationic-conducting neurons when exposed to solutions with fluctuating concentrations of sodium, calcium, potassium, magnesium, and protons/H+. TempoVol™ biosensor is introduced to the cells using proprietary methods and is expressed in the in abundance in the cell.

Applications:

  • Neurotoxicity testing for reporting cellular cationic fluctuations (such as calcium, protons/H+, potassium)
  • Phenotypic Assays 
  • Chemical compound or small molecules screening
  • Research and development on animal models for human diseases
  • Studying neural maturation, networking and function, and cations-mediated pathways.

Academic scientists receive a special rate!

Specifications: ~1.05x10^6 cells per 1ml of freezing medium (vial)

Long-term Storage: liquid nitrogen

Growth Properties: adherent

Technology used: an in-house developed proprietary feeder-free, serum-free, viral/genetic-elements-free, integration-free reprogramming method.

QC:
Sterility, Safety, (BioSafety Level 2), HIV/viruses, bacteria, fungi: negative
Cell viability post-thawing >90%

SKU202

Additional Information

Product Use TempoVol-iCort™ are intended for basic scientific research, drug discovery and therapeutics development use only. It is not a product for human testing or diagnostics.