Details
Sensory neurons belong to one of the most important neuronal subtypes in the human peripheral nervous system (PNS). In the PNS, these neurons are primarily responsible for conducting cations-mediated electrical activities. And they form networks that are responsible for a variety of motor and sensory mediated functions. They are are implicated in many disabling neurological disorders, including pain, sensory neuron diseases, amyotropic lateral sclerosis (ALS) and mechano-or-temperature sensing deficiencies.
Tempo’s iSenso™: human sensory neurons are derived from human dermal cells, using integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction and maturation conditions. Tempo’s iSenso™ cells are branched structures when plated as a monolayer in culture and express biomarkers such as beta-Tuj (neuronal specific), ASIC, NTRK, P2X4, P2X3, SCN9A, SCN10A, TRPA, TRPV1, CNR1, beta-endorphin, VIP, Neurokinin, and peripherin (qPCR data not shown). iSenso™ can be used under maturation conditions, co-culture conditions (with astrocytes or additional neuronal subtypes), and short-term functional characterization studies.
Applications:
- Disease modeling
- Toxicity testing
- Phenotypic Assays (e.g., expression of differentiation markers)
- Research and Development of cell therapies in animal models
- Studying neuronal differentiation, function, and myelination
- Molecular biomarker studies
Academic scientists receive a special rate!
Specifications: ~1.0x10^6 cells per 1ml of freezing medium (vial)
Long-term Storage: liquid nitrogen
Growth Properties: adherent
Starting Materials: human dermal/fibroblast cells were reprogrammed using a proprietary foot-print-free technology.
QC:
Sterility
Safety
HIV/viruses, bacteria, fungi: negative
Cell viability (>90%) post-thawing
Additional Information
| Product Use | Tempo-iSenso™ are intended for basic scientific research drug discovery, and therapeutics development use only. It is not a product for human testing or diagnostics. |
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