Tempo-iSenso™: Human iPS-derived Sensory Neurons

Sensory neurons belong to one of the most important neuronal subtypes in the human peripheral nervous system (PNS). In the PNS, these neurons are primarily responsible for conducting cations-mediated electrical activities.  And they form networks that are responsible for a variety of motor and sensory mediated functions. They are are implicated in many disabling neurological disorders, including pain, sensory neuron diseases, amyotropic lateral sclerosis (ALS) and mechano-or-temperature sensing deficiencies.

Tempo’s iSenso™: human sensory neurons are derived from human dermal cells, using integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction and maturation conditions. Tempo’s iSenso™ cells are branched structures when plated as a monolayer in culture and express biomarkers such as beta-Tuj (neuronal specific), ASIC, NTRK, P2X4, P2X3, SCN9A, SCN10A, TRPA, TRPV1, CNR1, beta-endorphin, VIP, Neurokinin, and peripherin (qPCR data not shown). iSenso™ can be used under maturation conditions, co-culture conditions (with astrocytes or additional neuronal subtypes), and short-term functional characterization studies.

Applications:

• Disease modeling

• Toxicity testing

• Phenotypic Assays (e.g., expression of differentiation markers)

• Research and Development of cell therapies in animal models

• Studying neuronal differentiation, function, and myelination

• Molecular biomarker studies

Academic scientists receive a special rate!

Specifications: ~1.0x10^6 cells per 1ml of freezing medium (vial)

Long-term Storage: liquid nitrogen

Growth Properties: adherent

Starting Materials: human dermal/fibroblast cells were reprogrammed using a proprietary foot-print-free technology.

QC:
Sterility
Safety
HIV/viruses, bacteria, fungi: negative
Cell viability (>90%) post-thawing