popular

Tempo-iMotorNer™: Human iPS-derived Motor Neurons

Availability: In stock

$825.00
OR

Summary

Tempo’s iMotorNer™ cells are reprogrammed from human iPS-derived multipotent progenitor cells, using integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary serum-free, virus-free, genetic-elements-free, and integration-free conditions. Motor neurons have synapses that transmit via cholinergic trasmitters. These synapses require extremely fast inactivations of its transmitter, acetylcholine (Ach), by utilizing the enzyme, acetylcholinesterase (AchT). AchT hydrolyzes acetylcholine to acetate and choline, as a way of inactivation. Tempo’s iMotorNer™ cells are polarized structures when plated as a monolayer in culture and express biomarkers, acetylcholinesterase (AchT), beta-TUJ (neuron-specific), Isl1 and HB9.


Academic scientists receive a special rate!

Tempo-iMotorNers, anti-acetylcholinesterase antibody against human AchT protein

More Views

  • Tempo-iMotorNers, anti-MAP2 antibody
  • Tempo-iMotorNers, Post-Thaw, 24-hours

Details

Tempo-iMotorNer™: Human iPS-derived Motor Neurons
Tempo’s iMotorNer™ cells are reprogrammed from human iPS-derived multipotent progenitor cells, using integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary serum-free, virus-free, genetic-elements-free, and integration-free conditions. Motor neurons have synapses that transmit via cholinergic trasmitters. These synapses require extremely fast inactivations of its transmitter, acetylcholine (Ach), by utilizing the enzyme, acetylcholinesterase (AchT). AchT hydrolyzes acetylcholine to acetate and choline, as a way of inactivation. Tempo’s iMotorNer™ cells are polarized structures when plated as a monolayer in culture and express biomarkers, acetylcholinesterase (AchT), beta-TUJ (neuron-specific), Isl-1 and HB9.

Applications:

  • Disease modeling (e.g., ALS/Lou Gerig's, Motor Neuron Disorders)
  • Toxicity testing
  • Phenotypic Screening (e.g., co-culture with muscle tubules)
  • In vitro assays using motor neurons
  • Developmental biomarker and co-culture (with myotube) studies

Academic scientists receive a special rate!

Technology used: an in-house developed proprietary feeder-free, serum-free, viral/genetic-elements-free, integration-free reprogramming method.

Specifications: ~1.02x10^6 cells per 1ml of freezing medium (vial)

Long-term Storage: liquid nitrogen

Growth Properties: adherent

Storage: remove cryovials (dry ice packaging) and place the vial into liquid nitrogen for storage. Alternatively, thaw and use the cells immediately.

QC: Sterility, Safety (BioSafety Level 2), HIV/viruses, bacteria, fungi: negative. Cell viability post-thawing (>90%)

Additional Information

Product Use Tempo-iMotorNer™ are intended for basic scientific research drug discovery, and therapeutics development use only. It is not a product for human testing or diagnostics.