Details
Dopaminergic neurons belong to one of the most important neuronal subtypes in the human central nervous system (CNS). In the CNS, these neurons
are primarily responsible for transmitting dopamine and they form networks that are responsible for a variety of functions in the substantia nigra, ventral tegmental area, hypothalamus, and zona incerta. They are implicated in many disabling neurological disorders, including Parkinson’s, drug addiction, psychosis, and Attention Deficit Hyperactivity Disorder (ADHD).
Tempo’s iDopaNer™: human dopaminergic neurons are derived from human dermal cells, using integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction and maturation conditions. Tempo’s iDopaNer™ cells are branched structures when plated as a monolayer in culture and express biomarkers such as beta3-Tuj (neuronal), tyrosine hydroxylase (TH), and dopamine transporter (DAT). iDopaNer™ can be used under maturation conditions, co-culture conditions (with astrocytes or additional neuronal subtypes), and short-term functional characterization studies.
Applications:
- Disease modeling
- Toxicity testing
- Phenotypic Assays (e.g., expression of differentiation markers)
- Research and Development of cell therapies in animal models
- Studying neuronal function
Long-term Storage: liquid nitrogen
Growth Properties: adherent
Technology used: an in-house developed proprietary feeder-free, serum-free, viral/genetic-elements-free, integration-free reprogramming method.
QC:
Sterility, Safety, (BioSafety Level 2), HIV/viruses, bacteria, fungi: negative
Cell viability post-thawing >90%
SKU206
Additional Information
| Product Use | Tempo-iDopaNer™ are intended for basic scientific research drug discovery, and therapeutics development use only. It is not a product for human testing or diagnostics. |
|---|
You have no items in your shopping cart.
