Biosensors

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  1. TempoVol in TempoRapid cells, image1

    TempoVol™-Rapid: Cationic Voltage Biosensor Assay using Immortalized Human Neuroepithelial Cells

    $595.00

    TempoVol™ cationic voltage biosensor responds as a fluorescent reporter: 605nm-625nm fluorescent range (Excitation/Emission: 610nm/625nm). It is incorporated into Tempo's proprietary immortalized human neuroepithelial cell line, TempoRapidTM. TempoVol™ control cells serve as a control for all products containing the TempoVol™ biosensor. This product can be used for single-cell applications, as well as medium to high-throughput screening platforms.

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  2. TempoVol responses

    TempoVol™-iNStem: Cationic Voltage Biosensor Assay using Human Neural Progenitor Cells

    $950.00

    TempoVolTM cationic voltage biosensors are incorporated into human neural progenitor cells. They respond to intracellular ionic changes in the 605nm-625nm fluorescent range (Excitation/Emission = 610nm/625nm), measuring increases or decreases in cytosolic calcium/potassium/proton/sodium concentrations. With excellent signal-to-noise ratios, these calcium biosensors can operate on second-to-minute scales. They can be used for single-cell applications, as well as medium to high-throughput screening platforms.

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  3. popular iPS-derived cortical neurons; ICC using anti-beta-Tuj

    TempoVol™-iCort: Cationic Voltage Biosensor Assay using Human Cortical Neurons

    $950.00

    TempoVol™-iCort: cationic voltage biosensor assay using human iPS-derived . They are derived from integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary neural induction and maturation conditions. TempoVol™-iCort cells are polarized structures when plated as a monolayer in culture and express markers such as MAP2 and beta-Tuj. We've validated iCort™ cells to be cationic-conducting neurons when exposed to solutions with fluctuating concentrations of sodium, calcium, potassium, magnesium, and protons/H+. TempoVol™ biosensor is introduced to the cells using proprietary methods and is expressed in the in abundance in the cell. Learn More
  4. popular TempoATP cells, Rotenone treated

    TempoATP™-Rapid: ATP Biosensor Assay

    $595.00

    TempoATP™, a fluorescent biosensor, is incorporated into Tempo's proprietary immortalized human neuro-epithelial cell line, TempoRapidTM . The biosensor assay offers fast kinetics (resolution is in seconds) in measuring real-time cellular ATP metabolism and cytotoxicity. Analysis of cellular oxidative phosphorylation directly reflects mitochondrial health and function.

    TempoATP™-Rapid cells serve as a control for all products containing the TempoATP™ biosensor. To customize TempoRapid™ cells to scientists’ experimental needs, the cells are easily transfectable with gene(s)-of-interest.

    For additional human cell lines and human cell types, please contact Tempo Support <support@tempobioscience.com>.

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  5. popular TempoO2-Rapid, ActinomycinA treated

    TempoO2™-Rapid: Oxygen Metabolism Biosensor Assay

    $595.00

    TempoO2™, a fluorescent biosensor, is incorporated into Tempo's proprietary immortalized human neuro-epithelial cell line, TempoRapid™. The biosensor assay offers fast kinetics (resolution: seconds to hours) in measuring real-time cellular metabolism and cytotoxicity. Analysis of cellular respiration directly reflects mitochondrial health and function. TempoO2™-Rapid cells serve as a control for all products containing the TempoO2™ biosensor. To customize TempoRapid™ cells to scientists’ experimental needs, the cells are easily transfectable with gene(s)-of-interest. For additional human cell lines and human cell types, please contact Tempo Support <support@tempobioscience.com>.

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  6. popular TempoATP™ and TempoMito™

    TempoDual™-ATPMito-Rapid: Dual Biosensor Cytotoxicity Assay

    $950.00

    TempoMito™ biosensor is an mitochondrial calcium flux sensor. The cells have been engineered to express TempoMito™ biosensor which has been developed for monitoring mitochondrial calcium flux and cytotoxicity using a highly sensitive fluorescent based biosensor as reporter. Excitation=610nm; Emission=625nm (Filter-based fluorescent multiplate readers). TempoMito™ biosensor is introduced to the cells using proprietary magneto-liposome mediated methods and is expressed in the mitochondria (using marker proteins such as COX IV).

    TempoATP™, a fluorescent biosensor, is also custom-incorporated into the human TempoRapid™cell line . With TempoATP™ , the biosensor assay offers fast kinetics (resolution is in seconds) in measuring real-time cellular ATP metabolism and cytotoxicity. Analysis of cellular oxidative phosphorylation directly reflects mitochondrial health and function. Excitation=535nm; Emission=550nm (Filter-based fluorescent multiplate readers).

    TempoRapid™ cells are immortalized human neural-epithelial cells. The biosensors are transiently expressed. Please send inquiries for stable cell line development to Tempo Support.

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  7. popular TempoCal™-control cells image1

    TempoCal™-Rapid: Calcium Biosensor Assay using Immortalized Human Neuroepithelial Cells

    $595.00

    TempoCal™ is a calcium biosensor that responds as a fluorescent reporter: 605nm-625nm fluorescent range (Excitation/Emission=610nm/625nm) . It is incorporated into Tempo's proprietary immortalized human cell line, TempoRapid™. TempoCal™-control cells serve as a control for all products containing the TempoCal™ biosensor. This product can be used for single-cell applications, as well as medium to high-throughput screening platforms.

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  8. popular TempoMito responses2

    TempoMito™-iNStem: Mitochondrial Biosensor Assay using Human Neural Progenitors

    $950.00

    TempoMito™-iNStem cells comprise mitochondrial biosensors incorporated into human iPS-derived neural progenitor cells. Mitochondrial dysfunctions have been implicated in human neurological and psychiatric disorders, and neural progenitor cells have been used as a cellular model. Tempo's biosensor responds to mitochondrial calcium changes and reports in the 605nm-625nm fluorescent range (Excitation/Emission) as calcium levels increase or decrease. With excellent signal-to-noise ratios, these sensors can operate on second-to-minute scales. This tool provides an efficient way of detecting changes in the mitochondrial organelle and enables high-throughput screening approaches for drug discovery and toxicology screening.

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  9. TempoCal™-iAstro; 1mM CaCl2

    TempoCal™-iAstro: Calcium Biosensor Assay using Human Astrocytes

    $950.00

    TempoCal™-iAstro: Tempo’s calcium biosensors are incorporated into induced human astrocytes. They respond to intracellular calcium changes in the 605nm-625nm fluorescent range (Excitation/Emission=610nm/625nm). With excellent signal-to-noise ratios, these biosensors operate on second-to-minute scales.

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  10. Immunocytochemistry with anti-COX IV antibodies

    TempoMito™-iAstro: Mitochondrial Biosensor Assay using Human Astrocytes

    $950.00

    TempoMito™-iAstro cells contain mitochondrial biosensors in human iPS-derived astrocytes. Disruption of mitochondrial functions in human astrocytes has been implicated in Alzheimer's disorder and ischemia. Tempo's biosensor responds to mitochondrial calcium changes and reports in the 605nm-625nm fluorescent range (Excitation/Emission) as calcium levels increase or decrease. With excellent signal-to-noise ratios, these sensors can operate on second-to-minute scales. This tool provides an efficient way of detecting changes in the mitochondrial organelle and enables high-throughput screening approaches for drug discovery and toxicology screening.

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