Tempo-iMel™: Human iPS-derived Melanocytes

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$695.00
OR

Summary

Tempo-iMel™: human melanocytes are derived from human dermal-fibroblast cells, using feeder-free, serum-free, genetic-elements-free, virus-free,  induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction and maturation conditions. Tempo’s iMel™ cells are branched elaborate structures when plated as a monolayer in culture and express biomarkers such as Vimentin, S100beta, and cytokeratins. iMel™ can be used under maturation conditions, co-culture conditions (with fibroblasts, keratinocytes or additional epidermal subtypes), and short-term functional characterization studies. 


Academic scientists receive a special rate!

iMel cells, ICC using anti-human-Vimentin, image 2

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  • Tempo-iMel cells in culture
  • iMel cells, ICC using anti-human-S100beta
  • iMel cells, ICC using anti-human-Vimentin
  • iMel cells, ICC using anti-human-S100beta, image 2

Details

Melanocytes are cells that produce melanin and they reside mostly in the epidermis (top) layer of human skin, as well as in the hair follicles and iris. Melanocytes form a heterogeneous group of cells, and they are also found in multiple regions in the human body (such as the inner ear). Their lineage as a cell type arises from neural crest cells. In the human skin, the ratio of melanocytes to keratinocytes is 1:10 (which is independent of ethnicity) in the epidermal basal layer.

Tempo-iMel™: human melanocytes are derived from human dermal-fibroblast cells, using feeder-free, serum-free, genetic-elements-free, virus-free,  induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction and maturation conditions. Tempo’s iMel™ cells are branched  elaborate structures when plated as a monolayer in culture and express biomarkers such as Vimentin, S100beta, and cytokeratins. iMel™ can be used under maturation conditions, co-culture conditions (with fibroblasts, keratinocytes or additional epidermal subtypes), and short-term functional characterization studies.

Applications:

  • Skin disease modeling
  • Toxicity testing
  • Phenotypic assays (e.g., expression of differentiation markers)
  • Mitochondrial dysfunction
  • Skin models (2D or 3D)
  • Bioprinting of skin
  • Research and Development of cell therapies in animal models
  • Studying epidermal function and melanin secretion

Academic scientists receive a special rate!

Specifications: ~1.25x10^6 cells per 1ml of freezing medium (vial)

Long-term Storage: liquid nitrogen

Growth Properties: adherent

Technology used: an in-house developed proprietary feeder-free, serum-free, viral/genetic-elements-free, integration-free reprogramming method.

QC:
Sterility, Safety, (BioSafety Level 2), HIV/viruses, bacteria, fungi: negative
Cell viability post-thawing >90%

SKU130

Additional Information

Product Use Tempo-iMel™ are intended for scientific research, research and development, drug discovery, and therapeutics development use only. It is not a product for human testing or diagnostics.