Tempo-iAstro™: Human iPSC-derived Astrocytes

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Astrocytes, also known as Astroglia, belong to the family of glial cells in the human central and peripheral nervous system. They have been shown to have central roles in the maintenance of neuronal metabolism and neurotransmitter synthesis. They have been implicated in many human neurodegenerative disorders such as multiple sclerosis, amyotrophic lateral sclerosis (ALS), Alzheimer’s disorder, Huntington’s disease and Parkinson’s disease.

Tempo’s iAstro™ cells are induced astrocytes reprogrammed from human fibroblasts or blood cells using proprietary stem cell reprogramming technologies. iAstro™ cells are cryopreserved at low passage numbers. Each vial contains >1 x 10cells. iAstro™ cells are characterized via standard morphological examinations and via immunocytochemistry methods against known marker proteins (such as GFAP and S100beta), and they exhibit calcium wave activities.

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iAstro (TM) human astrocytes, light transmission

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  • iAstro (TM) human astrocytes, anti-GFAP antibody
  • iAstro (TM) human astrocytes, anti-S100beta antibody
  • iAstro (TM) human astrocytes, light transmission
  • calcium imaging of human astrocytes


Tempo’s iAstro™: human iPSC-derived astrocytes are derived from integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary neural induction condition. Tempo’s iAstro cells are polarized structures when plated as a monolayer in culture and express astrocyte markers, GFAP and S100beta, and they exhibit calcium wave activities (see figures shown above).


  • Disease modeling
  • Toxicity testing
  • Phenotypic Screening (e.g., cytokine secretion, expression of differentiation markers)
  • Research and development of cell therapies in animal models
  • Studying astrocyte differentiation and function

Academic scientists receive a special rate! 

Specifications: ~1x10^6 cells per 1ml of freezing medium (vial)

Long-term Storage: liquid nitrogen

Growth Properties: adherent

Technology used: an in-house developed proprietary non-viral, nucleic-acids-free, feeder-free, serum-free, and integration-free reprogramming technology.

Storage: remove cryovials (dry ice packaging) and place the vial into liquid nitrogen for storage. Alternatively, thaw and use the cells immediately.

QC: Sterility, Safety (BioSafety Level 2), HIV/viruses, bacteria, fungi: negative. Cell viability post-thawing (>90%)



1) Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple Sclerosis

2) The Genetic Multiple Sclerosis (MS) Risk Variant rs7665090-G Increases Astrocyte Responses and Lymphocyte Recruitment to White Matter Lesions.

3) The Role of Astrocytes in Multiple Sclerosis. (Review)

4) New Research to Uncover Cellular Mechanisms Driving Risk for Multiple Sclerosis. (Review)

Additional Information

Product Use Tempo’s iAstro™ cells are intended for basic research and drug development use only. It is not a product for human therapeutics or diagnostics.